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Recent Publications

Complete publication list can be found at:

  • Song P, Peng W, Sauvé V, Fakih R, Xie Z, Ysselstein D, Krainc T, Wong YC, Mencacci NE, Savas JN, Surmeier DJ, Gehring K, Krainc D. Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. Neuron. 2023 Sep 13;S0896-6273(23)00629-3. PMID: 37716354.

  • Mahbub L, Kozlov G, Zong P, Lee EL, Tetteh S, Nethramangalath T, Knorn C, Jiang J, Shahsavan A, Yue L, Runnels L, Gehring K. Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15. Elife. 2023 Jul 14;12:e86129. PMID: 37449820.

  • Chen YS, Gehring K. New insights into the structure and function of CNNM proteins. FEBS J. 2023 May 24. PMID: 37222397.

  • Trempe JF, Gehring K. Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin. J Mol Biol. 2023 Jun 15;435(12):168090. PMID: 37054910.

  • Fakih R, Goldstein RH, Kozlov G, Gehring K. Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver​. J Biol Chem. 2023 Feb 22;299(4):103055. PMID: 36822330.

  • Fakih R, Sauvé V, Gehring K. Feedforward activation of PRKN/parkin. Autophagy. 2022 Jul 15:1-2.  PMID: 35838500.

  • Sauvé V, Sung G, MacDougall EJ, Kozlov G, Saran A, Fakih R, Fon EA, Gehring K. Structural basis for feedforward control in the PINK1/Parkin pathway. EMBO J. 2022 Jun 14;41(12):e109460. PMID: 35491809.

  • Fakih R, Sauvé V, Gehring K. Structure of the second phosphoubiquitin-binding site in parkin. J Biol Chem. 2022 Jul;298(7):102114.  PMID: 35690145.

  • Kozlov G, Mattijssen S, Jiang J, Nyandwi S, Sprules T, Iben JR, Coon SL, Gaidamakov S, Noronha AM, Wilds CJ, Maraia RJ, Gehring K. Structural basis of 3'-end poly(A) RNA recognition by LARP1. Nucleic Acids Res. 2022 Aug 18:gkac696. PMID: 35979957.

  • Vranas M, Lu Y, Rasool S, Croteau N, Krett JD, Sauvé V, Gehring K, Fon EA, Durcan TM, Trempe JF. Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria. Open Biol. 2022 Jan;12(1):210255. PMID: 35042405.

  • Kaisari S, Miniowitz-Shemtov S, Sitry-Shevah D, Shomer P, Kozlov G, Gehring K, Hershko A. Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2121478119. PMID: 35217622.

  • Gehring K, Kozlov G, Yang M, Fakih R. The double lives of phosphatases of regenerating liver: A structural view of their catalytic and noncatalytic activities. J Biol Chem. 2022 Jan;298(1):101471. PMID: 34890645.

  • Mattijssen S, Kozlov G, Fonseca BD, Gehring K, Maraia RJ. LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization. RNA Biol. 2021 Feb;18(2):259-274. PMID: 33522422.

  • Chen YS, Kozlov G, Moeller BE, Rohaim A, Fakih R, Roux B, Burke JE, Gehring K. Crystal structure of an archaeal CorB magnesium transporter. Nat Commun. 2021 Jun 29;12(1):4028. PMID: 34188059.

  • Gehring K, Miki H. Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity. Br J Cancer. 2021 Mar;124(6):1035-1036. PMID: 33268817.

  • Mattijssen S, Kozlov G, Gaidamakov S, Ranjan A, Fonseca BD, Gehring K, Maraia RJ. The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1. RNA Biol. 2021 Feb;18(2):275-289. PMID: 33292040.

  • Gehring K, Kozlov G, Yang M, Fakih R. The double lives of phosphatases of regenerating liver: A structural view of their catalytic and noncatalytic activities. J Biol Chem. 2022 Jan;298(1):101471. PMID: 34890645.

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